Targeted Approach to Overcoming Treatment Resistance in Advanced Prostate Cancer

Abstract

The purpose of this project is to determine if rescinnamine is effective against prostate cancer and treatment resistance. We determined that rescinnamine is less effective against prostate cancer than against other cancer types, making it less ideal to follow. In addition, the hypotensive activity of rescinnamine was dose-inhibitive in animal studies. We therefore pursued a combination of computational modeling, chemical synthesis and in vitro testing to identify analogs with higher efficacy and less toxicity. Initial results identified a small number of compounds, some of them entirely novel, that should be followed up on in subsequent studies.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2015
Accession Number
ADA621769

Entities

People

  • Karin Scarpinato

Organizations

  • Georgia Southern University

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Body Weight
  • Cell Physiological Processes
  • Chemical Synthesis
  • Chemistry
  • Confocal Microscopy
  • Crystal Structure
  • Mass Spectrometry
  • Methanols
  • Molecular Dynamics
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Toxicity

Fields of Study

  • Biology

Readers

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  • Prostate Cancer Biology.
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