Stem Cell Therapy for Healing Wounded Skin and Soft Tissues

Abstract

Exogenously applied stem cells can integrate into wounds, and if properly directed to regenerate tissue rather than to rapidly restore the barrier function, should be able to regenerate tissue for improved wound healing. We hypothesize that when applied topically to wounds, adult, adipose-derived mesenchymal stem cells that are directed toward tissue regeneration can reduce inflammation, increase angiogenesis, reduce scarring, and improve the restoration of skin functions. The goal of the proposed research is to define the function of stem cells alone or in atrix to promote healing by regeneration to improve wound repair outcomes.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2014
Accession Number
ADA621821

Entities

People

  • Kai P. Leung
  • R. G. Hale
  • Sun K. Hong
  • T. A. Mustoe

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Bone And Bones
  • Cell Physiological Processes
  • Cells
  • Connective Tissue
  • Health Services
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Stem Cells
  • Three Dimensional
  • Two Dimensional

Readers

  • Immunology and Pathology

Technology Areas

  • Biotechnology