Defining Translational Reprogramming in Tuberous Sclerosis Complex

Abstract

Tuberous sclerosis complex (TSC) is an autosomal dominant disease characterized by benign tumors in various tissues. The genes mutated in this disease, TSC1 and TSC2, encode tumor suppressors that are associated in a complex. The TSC1/2 complex, through its Rheb-GAP activity, is a critical negative regulator of mTORC1 under physiological conditions. Activation of mTORC1 positively stimulates cap-dependent mRNA translation via its downstream substrates S6K and 4E-BP. In our previous study, we demonstrated that TSC-mTORC1 signaling regulates the balance between cap-dependent and cap-independent translation. In this project, we aim to (1) Dissect the molecular linkage between mTORC1 and protein homeostasis; (2) Define the role of mTORC1 in ribosome dynamics and translational re-programming.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2015
Accession Number
ADA621822

Entities

People

  • Shu-Bing Qian

Organizations

  • Cornell University

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Computer Programming
  • Cytoplasm
  • Department Of Defense
  • Dynamics
  • Eukaryotes
  • Fungi
  • Gene Expression
  • Genetic Code
  • Genetics
  • Health Services
  • Medical Personnel
  • Organelles
  • Proteins

Fields of Study

  • Medicine

Readers

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