Effects of Early Acute Care on Autonomic Outcomes in SCI: Bedside to Bench and Back

Abstract

Early management of blood pressure (BP) may be critical to outcome after spinal cord injury (SCI), but evidence-based protocols are needed. Optimal early treatment and management of SCI has not been established in clinical practice, nor in animal models. Guidelines for management of BP in acute SCI have been influenced by the rather clear evidence of a relationship between hypotension and poor outcomes in TBI, and the aim of maintaining cerebral blood flow in the face of increased intracranial pressure (ICP), but doubt remains about what is best for SCI. This grant focuses on the following two hypotheses: 1) Episodes of low BP (measured by mean arterial pressure (MAP) and systolic BP) in the early management of clinical SCI predict worse long-term functional outcomes, and 2) spontaneous hypotensive episodes in the perioperative period of experimental SCI in rats will result in worse outcomes. Both clinical data and experimental modeling studies address these specific hypotheses.

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Document Details

Document Type
Technical Report
Publication Date
Oct 30, 2014
Accession Number
ADA622193

Entities

People

  • Michael S Beattie

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Animal Structures
  • Big Data
  • Blood Coagulation
  • Blood Flow
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Data Analysis
  • Data Science
  • Data Sets
  • Health Services
  • Information Science
  • Physiological Monitoring
  • Spinal Cord
  • Spinal Injuries
  • Statistical Analysis
  • Veins
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Neurotrauma and Rehabilitation Medicine.