Maximizing PTH Anabolic Osteoporosis Therapy

Abstract

The subject of this research is the need for improved osteoporosis therapies. The purpose of this study is to test the efficacy of parathyroid hormone (PTH) mono - therapy and PTH + anti-catabolic combination therapies on Nmp4 -/- and wild type (WT) mice . We have previously determined that Nmp4 represses the response of bone to osteoanabolics 1-3. The scope of th is research comprises the following specific aims: (i & ii) to determine the impact of Nmp4 on the efficacy of PTH mono - and combination therapies with bisphosphonates and the selective estrogen receptor modulator (SERM) raloxifene in ovariectomized (ovx) mice; (iii) to determine the cell type specific contributions to the enhanced response of the Nmp4 -/- mouse to these osteoporosis therapies.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2015
Accession Number
ADA622386

Entities

People

  • Joseph Bidwell

Organizations

  • Indiana University

Tags

DTIC Thesaurus Topics

  • Body Weight
  • Bone And Bones
  • Bone Diseases
  • Bone Marrow
  • Cells
  • Chemistry
  • Genetics
  • Health Services
  • Lymphocytes
  • Osteogenesis
  • Osteoporosis
  • Peptide Growth Factors
  • Stem Cells

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