Molecular Innovations Toward Theranostics of Aggressive Prostate Cancer

Abstract

The efforts during this period include 1) the exploration of dendrimers that provide water solubility in the presence of hydrophobic peptides (a limitation encountered in the previous period), 2) the production of dendrimers with a DOTA-chelating ligand that can host the imaging agent, and 3) production of candidate theranostic dendrimer-peptide platforms for the evaluation of biological activity. A new conjugation strategy has been developed and shown to be useful for making the proposed multivalent conjugates. Samples continue to be submitted to our collaborators for biological evaluation.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2014
Accession Number
ADA622389

Entities

People

  • Eric E Simanek

Organizations

  • Texas Christian University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • 1-Ring Heterocyclic Compounds
  • Amines
  • Boundaries
  • Chemical Synthesis
  • Chemistry
  • Dendrimers
  • Diagnostic Imaging
  • Hydrophilic Properties
  • Hydrophobic Properties
  • Macromolecules
  • Materials
  • Molecular Dynamics
  • Molecules
  • Organic Chemistry
  • Organic Solvents
  • Simulations
  • Solubility

Readers

  • Medical Imaging.
  • Molecular and Cellular Biochemistry
  • Systems Analysis and Design