Francisella DnaK Inhibits Tissue-Nonspecific Alkaline Phosphatase

Abstract

Pulmonary Franciscella infection resulted in reduction of plasma alkaline phosphatase activity. Franciscella heat shock protein DnaK binds to alkaline phosphatase thus reducing enzymatic activity, A Franciscella protein component responsible for alkaline phosphatase inhibition was identified. We present a novel mechanism used by a bacterial pathogen to evade the host's defense.

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Document Details

Document Type
Technical Report
Publication Date
Oct 26, 2012
Accession Number
ADA622474

Entities

People

  • Bernard P Arulanandam
  • Janakiram Seshu
  • Jieh-Juen Yu
  • Karl Klose
  • Sean P Leonard
  • Senthilnath L. Chetty

Organizations

  • United States Army Institute of Surgical Research

Tags

Communities of Interest

  • Counter WMD

DTIC Thesaurus Topics

  • Abstracts
  • Availability
  • Bacteria
  • Chemistry
  • Classification
  • Contracts
  • Gammaproteobacteria
  • Infection
  • Information Operations
  • Inhibition
  • Instructions
  • Microorganisms
  • Monitoring
  • Pathogenic Bacteria
  • Prokaryotes
  • United States
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Infectious Disease/Epidemiology
  • Molecular and Cellular Biochemistry