Characterizing and Targeting Replication Stress Response Defects in Breast Cancer

Abstract

During the fifth year of this project, we have successfully verified AXL protein as a reliable membrane marker for replication stress response defect (RSRD) breast cancer cells and we demonstrated the potential to use isotope-labeled anti-human AXL antibody to detect RSRD breast cancer cells in vivo. In addition, we have clearly demonstrated the in vivo therapeutic effects of MEK inhibitor, AZD6244, and ERK inhibitor, SCH772984 on targeting RSRD breast cancer cells in two xenograft mouse models

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2015
Accession Number
ADA622684

Entities

People

  • Chun Li
  • Chun-jen Lin
  • Hui Dai
  • Ju-Seog Lee
  • Shiaw-Yih Lin

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Biomedical Research
  • Body Weight
  • Breast Cancer
  • Cell Line
  • Detection
  • Inhibitors
  • Membrane Proteins
  • Membranes
  • Metallic Nanoparticles
  • Nanoparticles
  • Neoplasms
  • Particles
  • Proteins
  • Targeting
  • Tissues
  • Xenografts

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Nuclear Non-Proliferation and International Security
  • Oncology and Biomarker-Based Cancer Detection.