Advanced Development of Antiviral Prophylactics and Therapeutics (ADAPT) - Research Area 10

Abstract

The purpose of the proposed work is to continue the promising anti-hemorrhagic fever virus (HFV) drug discovery and lead optimization efforts previously initiated by Prosetta through significant advancement of at least two chemical series through the first critical steps toward filing a Investigational New Drug (IND) application: efficacy, safety and mechanism of action. This project will launch from the advanced platform of lead of optimization of five Prosetta-identified compounds and will progress through target identification and efficacy assessment in rodents. Two of these advanced compounds have very strong nanomolar-to-low micromolar activity against all four HFV families studied - Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae.

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Document Details

Document Type
Technical Report
Publication Date
Nov 17, 2014
Accession Number
ADA622748

Entities

People

  • Michael Farmer
  • Vishwanath R. Lingappa

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Cell-Free System
  • Cells
  • Cellular Structures
  • Contracts
  • Culture Techniques
  • Ebola Virus
  • Identification
  • Lead Compounds
  • Medical Personnel
  • Microsomes
  • Molecules
  • Protein-Protein Interactions
  • Rift Valley Fever
  • Tissue Extracts
  • Viral Structures
  • Virus Diseases
  • Viruses

Readers

  • Critical Infrastructure Protection in CBRN and WMD Threats.
  • Oncology
  • Virology (or Medical Virology).