A Multi-Scale Modeling and Experimental Program for the Dynamic Mechanical Response of Tissue

Abstract

We study the mechanical properties of collagen, which is the most prevalent protein in humans, and largely responsible for the mechanical properties of tissue. We use both a multiscale modeling approach, and experiments to examine the theoretical results. The atomistic structure of collagen is determined by Xray diffraction, which provides the starting point for atomistic simulations. These simulations are then used to predict the modulus of collagen fibrils. The bending modulus of fibrils is finally measured by using optical tweezers.

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Document Details

Document Type
Technical Report
Publication Date
Dec 09, 2014
Accession Number
ADA622970

Entities

People

  • David Gidalevitz
  • Jay D. Schieber
  • Joseph Orgel
  • Victor Perez-luna

Organizations

  • Illinois Institute of Technology

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Chemical Engineering
  • Chemistry
  • Computational Science
  • D Band
  • Elastic Properties
  • Engineering
  • Fluid Mechanics
  • Free Energy
  • Materials
  • Mathematical Models
  • Measurement
  • Mechanical Properties
  • Mechanics
  • Modulus Of Elasticity
  • Molecular Dynamics
  • Multiscale Modeling
  • Polymers

Readers

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