A Systems Biology Approach to Heat Stress, Heat Injury and Heat Stroke

Abstract

Heat illness is a major source of injury for military populations in both deployed and training settings. Developing tools to help leaders enhance unit performance while reducing the risk of injury is of paramount importance to the military. Here, we review our recent systems biology approaches to heat stress in order to develop a 3-dimensional (3D) realistic thermoregulation model, identify the molecular basis and mediators of injury, and characterize associated biomarkers. We discuss the implications of our work, future directions, and the type of tools necessary to enhance force health protection in the future.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2015
Accession Number
ADA622987

Entities

People

  • Danielle L. Ippolito
  • Jonathan D. Stallings

Organizations

  • U.S. Army Center for Environmental Health Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Biology
  • Blood
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Computational Biology
  • Gene Expression
  • Laboratory Animals
  • Metabolomics
  • Neurodegeneration
  • Proteins
  • Proteomics
  • Systems Biology
  • Three Dimensional
  • Traumatic Stress Disorder
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Distributed Systems and Data Platform Development
  • Exercise and Sports Science.
  • Joint Military Operations and Doctrine.