New Synthetic and Assembly Methodology for Guiding Nanomaterial Assembly with High Fidelity into 1D Clusters and 3D Crystals Using Biomimetic Interactions
Abstract
In year five of our grant we successfully completed a major grant milestone, and made progress and improvements in the areas where goals have previously been met. These accomplishments include: the first publication in the field on the self-assembly of quantum rods using DNA in which we used a patterned surface provided by DNA origami to control rod alignment and spacing (Section 1); published final results showing bioluminescence resonance energy transfer between firefly luciferase enzymes and rods that emit near infrared light (nIR), and improved long term stability and activity of the BRET nanoconjugates (Section 2). Finally, we completed a study that investigated ways to manipulate the 3D assembly of DNA-capped gold nanoparticles by using smart pH sensitive co-polymers, and transitioned that system to using elastin like polypeptides that have similar thermal- and pH responsive behavior (Section 3). We also successfully acquired and set-up an atomic force microscope purchased with AFOSR support. Two high impact articles were published, and one is in review. Four additional papers cite the grant, and three papers are in final stages of preparation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 26, 2015
- Accession Number
- ADA623003
Entities
People
- Mathew M. Maye
Organizations
- Syracuse University