Does RBC Storage Age Effect Inflammation, Immune Function and Susceptibility to Transfusion Associated Microchimerism in Critically Ill Patients? Adverse Effects of RBC Storage in Critically Ill Patients
Abstract
The study aim is to investigate specific mechanisms of potential adverse effects related to RBC storage age in critically ill patients. To date we have enrolled 120 out of 200 patients at the three clinical sites in Canada. We have recruited 1 new site and are in the process of recruiting 2 additional sites to improve enrollment rate. Samples have been collected, processed, and shipped from Canada to the repository at Blood Systems Research Institute (BSRI) in San Francisco, California. The repository consists of plasma, PBMCs and whole blood samples. The testing of patient samples for coagulation parameters, microparticles and microchimerism is in progress. Results from these tests will be correlated with clinical outcomes and study groups upon study completion.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2013
- Accession Number
- ADA623007
Entities
People
- Avani Shah
- Philip C Spinella
- Philip J Norris