Does RBC Storage Age Effect Inflammation, Immune Function and Susceptibility to Transfusion Associated Microchimerism in Critically Ill Patients? Adverse Effects of RBC Storage in Critically Ill Patients

Abstract

The study aim is to investigate specific mechanisms of potential adverse effects related to RBC storage age in critically ill patients. Enrollment has been completed since the last report. As of February 4, 2015, we have enrolled 100 of our goal of 100 subjects for testing of immune and coagulation parameters, and 153 of a goal of 200 patients for microchimerism testing. Samples have been collected, processed, and shipped from Canada to the repository at Blood Systems Research Institute (BSRI) in San Francisco, California. The repository consists of plasma, PBMCs and whole blood samples. Cytokine and coagulation testing has been completed for all 100 subjects outlined in the statement of work. Analysis of coagulation, micro particle, microchimerism and immune function testing on study samples is underway, and will be correlated with clinical outcome data shortly when that becomes available.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2014
Accession Number
ADA623008

Entities

People

  • Philip C Spinella
  • Philip J Norris

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Blood Transfusions
  • Continents
  • Cytokines
  • Department Of Defense
  • Geographic Regions
  • Health Services
  • Inflammation
  • Information Operations
  • Microparticles
  • North America
  • Particles
  • Standards
  • Statistical Analysis
  • Storage

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Trauma Surgery or Emergency Medicine.