Air Force Research Laboratory Integrated Omics Research

Abstract

Integrated Omics research capabilities within the Air Force Research Laboratory began in 2003 with the initiation of a Defense Technology Objective (DTO) project aimed to identify biomarkers of toxicity occurring within the warfighter as a pre-clinical indicator. Current methods for determining toxic exposures are not responsive enough or created available for deployment to prevent serious health effects. By using Integrated Omics (Genomics/Epigenetics, Proteomics, and Metabonomics) for biomarker discovery, we have identified specific molecular markers which, once validated, could be used for real-time or near real-time monitoring of the human response to uncharacterized exposures. The determination and use of validated biomarker sets, when installed on a fieldable biomonitor system, could allow fast determination of sub-clinical organ damage in response to chemical exposures. Since initiation of this program, our group has applied Omics technologies for biomarker discovery in a number of toxicology and human performance projects, including jet fuel exposures and cognitive fatigue.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
ADA623030

Entities

People

  • Camilla A. Mauzy
  • Nicholas J. Delraso
  • Pavel A. Shiyanov
  • Victor T. Chan

Organizations

  • Air Force Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Research Laboratories
  • Chemical Analysis
  • Chemistry
  • Computational Biology
  • Computational Science
  • Data Mining
  • Department Of Defense
  • Epigenetics
  • Gene Expression
  • Genomics
  • Liquid Chromatography
  • Mass Spectrometry
  • Metabolomics
  • Military Research
  • Motor Skills
  • Proteomics

Readers

  • Distributed Systems and Data Platform Development
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.

Technology Areas

  • Biotechnology