Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined Malaria Proteins

Abstract

In the past year of the project we have successfully produced recombinant VAR2CSA that binds with high affinity and high specificity to breast cancer cells and breast cancer tissue biopsies. We have demonstrated that the protein binds to distinct secondary modified proteoglycans exclusively present on breast cancer cells and that targeting these with recombinant VAR2CSA interferes with key functions of the cancer cell like growth, migration and invasion.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2014
Accession Number
ADA623354

Entities

People

  • Mads Daugaard

Organizations

  • BC Cancer Agency

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Blood Cells
  • Breast Cancer
  • British Columbia
  • Cancer
  • Carbohydrates
  • Cell Line
  • Cell Movement
  • Cells
  • Malaria
  • Neoplasms
  • Oncology
  • Polysaccharides
  • Proteins
  • Targeting
  • Tissues

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and Cellular Biochemistry
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech