The Neurophysiology of Autonomic Dysfunction in SCI: Plasticity in the Input and Output Neurons

Abstract

The overall aim of this research project was to evaluate neural plasticity in the nociceptive input afferents and preganglionic sympathetic output neurons in autonomic dysfunction following spinal cord injury (SCI). Over the last three years, we have characterized the physiological changes in cardiovascular responses after cenicalspinalcord injury and matched those with anatomical chargers (spouting) in nociceptive cutaneous aferents compared to the basline physiology and anatomy of this system in normal animals. In regards to the preganglionic sympathetic output neurons, we have developed a monoaminergic receptor profile for these neurons and measured sensorimotor plasticly in those neurons in an in vitro preparation.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2014
Accession Number
ADA623381

Entities

People

  • Keith E Tansey

Organizations

  • Emory University

Tags

Communities of Interest

  • Air Platforms
  • C4I
  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Animal Structures
  • Autonomic Nervous System
  • Brain
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Cells
  • Chemistry
  • Membrane Potentials
  • Nervous System
  • Neural Pathways
  • Neurology
  • Neurons
  • Neuroplasticity
  • Neurosciences
  • Peripheral Nervous System
  • Spinal Injuries
  • Stem Cells

Fields of Study

  • Medicine

Readers

  • Neuroscience