Targeted, On-Demand Charge Conversional Nanotherapeutics for Advanced Prostate Cancer
Abstract
In this project, we have proposed to design and test an innovative nanotherapeutic system to attack prostate cancer occurred in skeletal tissue. The proposed targeted, bio-responsive nanotherapeutics are based on peptide-functionalized diblock copolymers of poly(ethylene glycol) and poly(trimethenecarbonate) (PEG-PTMC) as the drug carrier, by using docetaxel as the therapeutic agent. During the past funding period, copolymers with predetermined terminal functionality, molecular weights and chemical compositions have been synthesized, and the physicochemical properties of nanotherapeutics including drug loading capacity and drug release profile have been investigated. The peptide functionalized nanotherapeutics possess high HA binding affinity, indicating their good bone-targeting capacity. We have investigated and evaluated biological activities of the drug-loaded nanotherapeutics in terms of cellular uptake and tumor inhibition in cultured prostate cancer cells. We have also initiated bone uptake and retention of the proposed nanotherapeutics in mice. For the future study, we will further perform therapeutic efficacy studies in vivo, such as survival study and bone-related therapeutic evaluation of bone-targeted nanotherapeutics to improve therapy for advanced prostate cancers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2015
- Accession Number
- ADA623384
Entities
People
- Xiuli Wang
Organizations
- University of Utah