A Model of Medical Countermeasures for Organophosphates

Abstract

This paper describes a toxicokinetic/dynamic model of inhaled, intravenous, and percutaneous exposure to several organophosphates (OPs). The model predicts the efficacy of medical countermeasures via a pharmacokinetic/dynamic model of oxime, anticholinergic, anticonvulsant, and bioscavenger treatment regimens.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
ADA623485

Entities

People

  • Gene E. Mcclellan
  • Jason Rodriguez

Organizations

  • Applied Research Associates (United States)

Tags

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Blood
  • Casualties
  • Central Nervous System
  • Chemical Warfare
  • Chemical Warfare Agents
  • Computer Programs
  • Department Of Defense
  • Equations
  • Health Services
  • Nerve Agents
  • Nervous System
  • Peripheral Nervous System
  • Poisoning
  • Rodents
  • Skeletal Muscle
  • Therapy

Readers

  • Computational Modeling and Simulation
  • Neurotoxicology