A Model of Medical Countermeasures for Vesicant Exposure

Abstract

This paper describes a toxicokinetic/dynamic model of percutaneous exposure to several vesicants. The model also predicts the efficacy of proposed medical countermeasures via a pharmacokinetic/dynamic model of scavenger, cell-cycle inhibitor, PARP inhibitor, protease inhibitor, and anti-inflammatory treatment regimens.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
ADA623488

Entities

People

  • Gene E. Mcclellan
  • Glen I. Reeves
  • Jason Rodriguez

Organizations

  • Applied Research Associates (United States)

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemical Synthesis
  • Chemical Warfare Agents
  • Chemistry
  • Computer Programs
  • Enzyme Inhibitors
  • Epithelial Cells
  • Eye Injuries
  • Medical Countermeasures
  • Programmed Cell Death
  • Rodents
  • Therapy

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Neurotoxicology
  • Neurotrauma and Rehabilitation Medicine.