Chemical Countermeasures for Antibiotic Resistance
Abstract
New approaches are required to control multi-drug resistant (MDR) bacterial infections in military medical facilities, as injured Warfighters are highly susceptible to such infections. 2-Aminoimidazole compounds that, at low micromolar levels and in conjunction with conventional antibiotics, will inhibit and disperse biofilms from both Gram-positive and Gram-negative pathogens, and re-sensitize MDR variants of these pathogens to FDA approved antibiotics are being developed and a number of analogues that suppress antibiotic resistance in MRSA, A. baumannii and P. aeruginosa have been identified. The activity of lead compounds has been characterized and investigations into the mechanisms of action carried out. The lead compounds do not exhibit hemolytic activity or toxicity in cell line assays. Large-scale synthesis and formulation has been performed to allow in vivo toxicity and efficacy to be evaluated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2015
- Accession Number
- ADA623887
Entities
People
- Andrew Yeagley
- Christian Melander
- Christopher Bracket
- Kara Mccolough
- Lingling Peng
- Robert Furlani
- Roberta J. Melander
- Rui Su
- Tyler L. Harris
- Zhaoming Su
Organizations
- North Carolina State University