The Root Cause of Post-traumatic and Developmental Stress Disorder, Phase 2

Abstract

Our overarching scientific hypothesis holds that serotonergic influences on brain development driven by genetics and early experience induce a variation of normal brain anatomy that makes the brain highly susceptible to the effects of severe stress. We are studying this question using both clinical and basic approaches. New findings from our lab funded by VA support the existence of an anatomical phenotype conferring susceptibility to depression, and the current work seeks to extend these findings to PTSD. After TATRC review in January of 2011, a revised research plan was developed to include a pre/post-deployment study at Fort Hood and anatomical studies of PTSD in collaboration with NIMH, Yale and USUHS. The revised budget was resubmitted in February and we are awaiting release of funds from contracting to begin the work, which in year 1 of this budget includes work on PTSD bioinformatics.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA623901

Entities

People

  • Keith A. Young

Organizations

  • Texas A&M University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Active Duty
  • Biological Sciences
  • Biology
  • Biomedical Information Systems
  • Biomedical Research
  • Clinical Trials
  • Computational Biology
  • Congenital Hereditary And Neonatal Diseases And Abnormalities
  • Department Of Defense
  • Deployment
  • Depression
  • Diseases And Disorders
  • Genes
  • Genetic Phenomena
  • Genetic Structures
  • Genetics
  • Phenotypes

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Neuroscience
  • Systems Analysis and Design

Technology Areas

  • Biotechnology