Mobile, Multi-modal, Label-Free Imaging Probe Analysis of Choroidal Oximetry and Retinal Hypoxia

Abstract

Coherent anti-stokes Raman spectroscopy (CARS) can be used to detect differences in the oxygen content in aqueous hemoglobin solutions. Our current setup is not ideal for accurately calibrating these measurements, but changes in the microscope setup and in the addition of gaseous oxygen to the physical sample are promising next steps.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
ADA624123

Entities

People

  • Jared C. Gilliam
  • Stephen T. Wong

Organizations

  • Houston Methodist Research Institute

Tags

DTIC Thesaurus Topics

  • Air Guns
  • Air Pressure
  • Biochemistry
  • Biological Markers
  • Biomedical Research
  • Blast Injuries
  • Calibration
  • Cell Physiological Processes
  • Chemical Compounds
  • Chemistry
  • Confocal Microscopy
  • Hemoglobin
  • Measurement
  • Microscopes
  • Proteins
  • Raman Spectroscopy
  • Spectroscopy

Fields of Study

  • Physics

Readers

  • Chemistry (specifically Chemical Fluorescence)
  • Combustion science or combustion engineering.
  • Medical Imaging.