Identification of Biomarkers Associated with the Healing of Chronic Wounds. Addendum

Abstract

It is the objective of this study to identify the biomarkers associated with the earliest stages of healing in chronic wounds. The findings of this study are intended to facilitate the development a diagnostic tool, which could be used to evaluate the healing process. Samples have been collected from interior and peripheral wound sites over 6 weeks from 50 subjects thus far and analyzed using 2D Page, iTRAQTM, and antibody arrays. Different proteins have been identified in healed versus chronic wounds and in different locations within the wounds. The correlation of wound biochemistry, clinical appearance, and clinical outcome is critical to the understanding of pressure ulcer healing. These findings will aid in the development of criteria for evaluating the healing process and response to treatment.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2009
Accession Number
ADA624152

Entities

People

  • Laura E. Edsberg

Organizations

  • Daemen University

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Biochemistry
  • Biological Markers
  • Biomedical Research
  • Cell Physiological Processes
  • Chemical Compounds
  • Chemistry
  • Dermatologic Agents
  • Identification
  • Molecules
  • Proteins
  • Proteomics
  • Skin Diseases
  • Therapy
  • Tissues
  • Two Dimensional
  • Wound Healing

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Infectious Disease/Epidemiology
  • Oncology and Biomarker-Based Cancer Detection.