Early Support of Intracranial Perfusion
Abstract
This report represents the sixth in a multi-year effort to improve outcomes in patients with traumatic brain injury (TBI) utilizing human and animal models. The first two years focused on infrastructure development, development of a basic science protocol, development and institution of two human use protocols, staff acquisition, equipment purchase and development of a Brain Resuscitation Registry (BRR) to provide structure and linkage capabilities for data collection and outcome reporting. Year 3 accomplishments included the ongoing enrollment of human use protocol subjects focusing on the inflammatory process following TBI and vital sign response to trauma, development and implementation of 2 retrospective human use protocols, processing of specimens, further development of the BRR and initiation of the basic science model including both small and large animal models of polytrauma. During Year 4 the existing human use protocols concluded data collection and neared finalization of data analysis, and a new protocol was proposed. Progress continued in BRR development and reporting, and the animal sub-project neared completion. Year 5 saw completion of data analysis for the Cytokines and Animal sub-projects, ongoing analysis of the Vital Signs sub-project, and continued development of the final human use sub-project. Year 6 focused on implementation and data collection for the final human use protocol, and finalization of data analysis for the Vital signs sub-project.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA624176
Entities
People
- Deborah Stein
- Karen Murdock
- Lisa Gettings
- Thomas Scalea
Organizations
- University of Maryland, Baltimore