Treating Combat Hearing Loss with Atoh1 Gene Therapy
Abstract
The goal of the project is to test experimental therapies for hearing loss in transgenic mouse models. We have identified a list of targets of the Atoh1 transcription factor which is a key to regenerating hair cells. We have shown that another candidate pathway, the Notch signaling pathway, is no longer active in the mature animal, and thus is not a viable therapeutic target for hearing loss. We have also generated the means to activate Atoh1 and a supporting factor, Gfi1, in deafened mice to promote hair cell regeneration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2015
- Accession Number
- ADA624177
Entities
People
- Andrew K. Groves
Organizations
- Baylor College of Medicine