A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury

Abstract

A small, lightweight microdevice has been developed for activity-dependent stimulation (ADS) and successfully tested for functionality in both anesthetized and ambulatory rats. Further, in semi-chronic experiments in rats with traumatic brain injury (TBI) using this microdevice, an unprecedented, potent effect of ADS on motor performance has been demonstrated, as compared to control rats (injured but no microdevice) and open-loop stimulation (OLS) rats. Specifically, OLS does result in some recovery after injury, but ADS is significantly more efficacious, resulting in recovery to normal ranges of performance within 2 weeks after injury. In the final stage of this funding period, we will prepare to extend these findings to non-human primates as we finalize a) the optimal parameters for the primate TBI model and b) the design and construction of the primate microdevice.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2014
Accession Number
ADA624274

Entities

People

  • Pedram Mohseni
  • Randolph J Nudo

Organizations

  • Case Western Reserve University

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical

DTIC Thesaurus Topics

  • Application-Specific Integrated Circuits
  • Brain
  • Brain Injuries
  • Cerebral Cortex
  • Computer Programming
  • Computer Science
  • Computers
  • Digital Signal Processing
  • Diseases And Disorders
  • Electrical Engineering
  • Field Programmable Gate Arrays
  • Integrated Circuits
  • Medical Personnel
  • Neural Engineering
  • Neuroplasticity
  • Neurosciences
  • Signal Processing

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