Matrix Metalloproteinases as a Therapeutic Target to Improve Neurologic Recovery After Spinal Cord Injury

Abstract

We are evaluating efficacy of GM6001, a matrix metalloproteinase (MMP) inhibitor in a murine model of spinal cord injury (UCSF) and in dogs (Texas A & M, TAMU) that sustain naturally occurring spinal cord injuries resulting from spontaneous intervertebral disk herniation (IVDH). Scope: These studies focus on efficacy of GM6001 in the context of an optimal therapeutic window and dependency on injury severity, using clinically relevant neurologic and urologic outcome measures.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA624276

Entities

People

  • Aida F. Martinez
  • Alpa Mahuvakar
  • Jon Levine
  • Linda J. Noble
  • Thomas Fandel

Organizations

  • University of California, San Francisco

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Body Weight
  • Brain Injuries
  • Chemical Synthesis
  • Chemistry
  • Clinical Trials
  • Data Analysis
  • Health Services
  • Information Science
  • Inhibition
  • Spinal Cord
  • Spinal Injuries
  • Spine
  • Statistical Analysis
  • Therapy
  • Urinary Tract
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics
  • Neurotrauma and Rehabilitation Medicine.