Mechanistic Links Between PARP, NAD, and Brain Inflammation After TBI

Abstract

This project is a pre-clinical evaluation of the efficacy of veliparib and NAD as agents for suppressing inflammation and improving outcomes after traumatic brain injury. The animal models include pig and rat models of controlled cortical impact and blast injury. Work completed in this year 2 (of 3) includes the large majority of the pig CCI and blast studies, and all rat veliparib animal surgeries. The behavioral analyses for these is completed, and the histological analyses are ongoing. Rat blast studies are ongoing. The studies using NAD as an anti-inflammatory agent have also been initiated. Results of the studies completed confirm that veliparib and NAD attenuate microglial activation after both blast and CCI. Veliparib improves outcome on some of the elevated plus maze and several aspects of the 5-choice reaction test when administered within 2 hours of injury. Analysis of long term (2-month) survival is ongoing.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
ADA624298

Entities

People

  • Raymond A. Swanson

Organizations

  • Northern California Institute for Research and Education

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Inflammatory Agents
  • Biomedical Research
  • Blast Injuries
  • Blast Tubes
  • Brain
  • Brain Injuries
  • California
  • Cell Physiological Processes
  • Computer Vision
  • Department Of Defense
  • Education
  • Gene Expression
  • Inflammation
  • Medical Personnel
  • Object Recognition
  • Professional Development
  • Test And Evaluation

Fields of Study

  • Biology

Readers

  • Clinical Trial Research.
  • Toxicology/Environmental Toxicology
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.