Divergent Effects of Dendritic Cells on Pancreatitis
Abstract
Numbers dendritic cells (DCs) increased 100-fold in pancreata of mice with acute pancreatitis to account for nearly 15% of intrapancreatic leukocytes. Intrapancreatic DCs acquired a distinct immune phenotype in mice with acute pancreatitis; they expressed higher levels of major histocompatibility complex II and CD86 and increased production of interleukin-6, MCP 1, and TNFa. DC over-expansion exacerbated disease. However, DCs were also required for pancreatic viability; the exocrine pancreas died in mice that were depleted of DCs and challenged with caerulein or L-arginine. All mice with pancreatitis that were depleted of DCs died from acinar cell death within 4 days. These data suggest that DC have simultaneous paradoxical pro-inflammatory and protective effects in pancreatitis. Further investigations are warranted.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2015
- Accession Number
- ADA624310
Entities
People
- George Miller
Organizations
- New York University