GC-MS/MS Analyses of Biological Samples in Support of Developmental Toxic Effects on Subcutaneous Exposure of Rats to GB

Abstract

This report documents the results of gas chromatography tandem mass spectrometry analyses of blood, tissues, and organs (heart, lung, liver, kidney, brain, eye, and diaphragm) that were obtained from rats (postnatal days 7, 14, 21, 42, and 70) after their exposure to various concentrations of sarin (GB) via subcutaneous injection. The amounts of free and regenerated GB present in these biological samples were quantified using chemical ionization mass spectrometry with isotope dilution.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2015
Accession Number
ADA624375

Entities

People

  • Jeffrey M. Mcguire
  • Linnzi K. Wright
  • Lucille A. Lumley
  • Michael W. Busch
  • Paul S. Demond

Organizations

  • Edgewood Chemical Biological Center

Tags

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Age Groups
  • Biomedical Research
  • Blood
  • Blood Cells
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chromatography
  • Gas Chromatography
  • Health Services
  • Mass Spectrometry
  • Medical Personnel
  • Nerve Agents
  • Skeletal Muscle
  • Spectrometry
  • Spectroscopy
  • Tissues

Fields of Study

  • Chemistry

Readers

  • Aerosol Science/Aerosol Physics
  • Cardiovascular Physiology
  • Molecular and Cellular Biology