Neurocognitive Effects of Radiotherapy
Abstract
This report describes continued work on the award Neurocognitive Effects of Radiotherapy , which examines the neurocognitive and imaging impact of proton therapy for patients will low grade glioma and base of skull meningioma. A total of 21 patients have been enrolled: 8 patients in the skull base cohort 1 [2 female photon and 6 (2 male; 4 female) protons], 4 female and 1 male patient in the low grade glioma/meningioma cohort 2 and 9 (6 male, 3 female) control patients. We continue to achieve continuous enrollment with 4 of the above 21 patients enrolled during the most recent quarter (July, August, September 2013). All patients have completed a 4-5 hour neurocognitive testing assessment at baseline by Dr. Carol Armstrong. In addition, all patients have completed a 1 hour standard MRI as well as additional testing including diffuse tensor imaging (DTI), perfusion and diffusion. The majority of patients have completed baseline and at least two additional time-points in regards to both neurocognitive testing and MRI. Although data are preliminary, neurocognitive results for 15 subjects (9 proton, 6 control) indicate no indication of deterioration in procedural learning or complex attention from pre-proton baseline to 1.5 months after completing radiation based on the Serial Response Test and Audiovisual Attention Shift task, respectively. The Timing Function (TF) test indicates that patients may be less accurate in time perception than controls; however, it also demonstrates a trend of recovery in this skill from pre-proton baseline to 1.5 months after radiation. All three of these tests are experimental and require validation in this particular setting. Based on these preliminary data, all three appear reliable, with the TF test appearing most sensitive for change over time in patients, while providing stable results in controls. Imaging analysis has been carried out independently from neurocognitive analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 05, 2013
- Accession Number
- ADA624390
Entities
People
- Alexander Lin
- Carol Armstrong
- Harish Poptani
- Lilie Lin
- Manoj Kumar
- Michelle Alonso-basanta
- Robert Lustig
- Ron Wolf
- Tim Zhu
- Zelig Tochner
Organizations
- University of Pennsylvania