Endophenotypes of Dementia Associated with Traumatic Brain Injury in Retired Military Personnel
Abstract
Our goal is to define the clinical phenotype of cognitive impairment in older veterans who have been exposed toTBI. Our hypothesis is that TBI in early to mid-life is associated with a clinical phenotype that has features distinguishable from AD. In the first year, we completed the screening survey portion of the study and found that over half of the veterans surveyed (n=298) had a history of head injury, with over 20% requiring hospitalization. Those with TBI were more likely to report mood, anxiety, substance use disorder, and PTSD symptoms over the course of their lifetime, have active PTSD symptoms, and have subjective memory complaints (all p < 0.05). A manuscript based on these results has been submitted to a peer-reviewed journal. Data collection for the cross-sectional study phase is finished (n=71 controls, n=75 TBI). The main analysis is complete and a manuscript describing the clinical phenotype of TBI in older veterans is nearly ready for submission. Another manuscript, detailing the neuropsychological results, is in preparation. The results of this study show that older veterans with past TBI have a specific clinical and neuropsychological phenotype, which has relevance for future treatment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2015
- Accession Number
- ADA624475
Entities
People
- Kristine Yaffe
Organizations
- Northern California Institute for Research and Education