Pupillometry and Saccades as Objective mTBI Biomark

Abstract

The objective of the study is to validate pupillary light reflex (PLR), saccadic and convergence eye movements as objective biomarkers for the identification of Warfighters with acute mild traumatic brain injury (mTBI) using commercial-off-the-shelf (COTS) instruments: infrared pupillometers, King-Devick (KD) test and near point of convergence (NPC) rule, respectively. Hundred mTBI and 100 age-matched non-TBI (controls) military personnel are to be recruited from the patient population at Womack Army Medical Center (WAMC). This study was designed determine within each group the effectiveness of these tests, individually and/or in combination, to correctly identify mTBI in agreement with the mTBI diagnosis made by the WAMC Department of Brain Injury Medicine. Preliminary results showed that three of the eight PLR parameters are statistically different between the groups: average constriction velocity, average dilation velocity, and 75% dilation recovery time. In addition, the KD test, NPC rule, and the CISS survey showed sensitivity in identifying military personnel with mTBI.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
ADA624533

Entities

People

  • José E. Capó-aponte

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Agreements
  • Anxiety Disorders
  • Biological Markers
  • Biomedical Research
  • Brain Injuries
  • Constrictions
  • Convergence
  • Department Of Defense
  • Diseases And Disorders
  • Eye
  • Eye Movements
  • Identification
  • Institutional Review Board
  • Medical Personnel
  • Military Personnel
  • Recovery
  • Traumatic Stress Disorder

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Medical or Health Care Field.
  • Neurotrauma and Rehabilitation Medicine.