Bottom-up Assembly of Engineered Protein Fibers

Abstract

Inspired by nature's approach to biomaterials synthesis, we employ a bottom up assembly of proteins to fabricate defined fibers that are robust and stable. We have decorated these protein fibers with bioorthogonal chemical moieties in the form of unnatural amino acids to achieve stability in fiber assembly and defined inorganic protein complexes with magnetic properties. The resulting set of proposed biopolymers bear tremendous impact in understanding the principles for designing highly robust protein fibers in general. Moreover, the coupling of inorganic materials with biomaterials provides a means for patterning magnetite crystals on assemblies.

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Document Details

Document Type
Technical Report
Publication Date
Feb 15, 2015
Accession Number
ADA625384

Entities

People

  • Jim Montclare

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Assembly
  • Chemical Synthesis
  • Chemistry
  • Engineering
  • Gene Delivery
  • Magnetic Properties
  • Materials
  • Materials Processing
  • Materials Science
  • Metallic Nanoparticles
  • Molecules
  • Nanoparticles
  • Nanotechnology
  • Self Assembly
  • Small Molecules
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  • Molecular and Cellular Biochemistry
  • Nanocomposite Materials Science