Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid Muscle Inhibition

Abstract

The sublaterodorsal (SLD) nucleus is hypothesized to induce muscle atonia during rapid eye movement (REM) sleep. This was tested by injecting channelrhodopsin into the SLD of 5 rats, followed by a series of behavioral tests. Results confirmed our ability to rapidly induce muscle atonia following optogenetic stimulation of the SLD, suggesting that activation of the SLD is sufficient to cause a REM atonia like state.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2015
Accession Number
ADA625406

Entities

People

  • Cameron H. Good
  • Nathan Burnham
  • Thomas Jhou

Organizations

  • Medical University of South Carolina

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Body Regions
  • Body Weight
  • Boundaries
  • Brain
  • Cells
  • Data Analysis
  • Electroencephalography
  • Eye
  • Eye Movements
  • Fibers
  • Human Factors Engineering
  • Inhibition
  • Military Research
  • Optical Fibers
  • South Carolina
  • Surgery

Fields of Study

  • Biology
  • Psychology

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Neuroscience