The Roles of the Bone Marrow Microenvironment in Controlling Tumor Dormancy

Abstract

The purpose of this study is to identify the mechanisms whereby the bone marrow microenvironment is involved in regulation of tumor dormancy. Aim1 will identify and explore how DTCs stay dormant for long periods of time. We postulate that DTCs drive the bone marrow niche into dormancy through the GAS6 pathway. Aim2 will determine how DTCs escape dormancy, consequently rendering them more susceptible to the chemotherapy. As a major accomplishment of this study during this period is that the PI, Dr. Yusuke Shiozawa, accepted a position as an Assistant Professor at Wake Forest School of Medicine as of 03/01/15. The PI obtained the necessary institutional approvals (IACUC, IRB, IBC) and submitted the grant transfer request (06/11/2015) to gain approval from the Department of Defense for a transfer of the award from the University of Michigan to Wake Forest School of Medicine. As a result, the progress of this award was suspended at Wake Forest School of Medicine during this period of time. Once the PI obtains the grant transfer approval from the Department of Defense, he will initiate the proposed research as soon as possible.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
ADA625478

Entities

People

  • Yusuke Shiozawa

Organizations

  • Wake Forest University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Bone Marrow
  • Bones
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Culture Techniques
  • Department Of Defense
  • Law
  • Medical Personnel
  • Michigan
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Schools
  • Stem Cells
  • Universities

Readers

  • Clinical Trial Research.
  • Data Mining and Knowledge Discovery.
  • Oncology (Cancer Research).