Investigation the Regulation and Potential Role of Nonhypoic Hypoxia-Inducible Factor 1 (HIF-1) in Aromatase Inhibitor-Resistant Breast Cancer

Abstract

During the 2013-2014 period of the grade evidence is provided that HER2 and HIF-1alpha expression are temporally correlated in vivo in letrozole-treated tumor xenografts. In addition, further evidence is provided that nonhypoxic HIF-1 is involved in regulating cancer stem cell characteristics in letrozole-resistant breast cancer cells, as specific inhibition of HIF-1alpha by EZN-2968 decreased cancer stem cell characteristics (i.e., microtentacle expression. However, HIF-1alpha does not seem to be associated with the vimentin promoter in LTLTCa cells, though it regulates its expression. Which suggests that HIF-1alpha may regulate this vimentin through an intermediary protein.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA625486

Entities

People

  • Armina A. Kazi

Organizations

  • University of Maryland, Baltimore

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cells
  • Chromosome Structures
  • Clinical Trials
  • Culture Techniques
  • Growth Factors
  • Inhibition
  • Inhibitors
  • Neoplasms
  • Proteins
  • Regulations
  • Stem Cells
  • Transcription Factors
  • Xenografts

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology (Cancer Research).
  • Rocket Propulsion.

Technology Areas

  • Biotechnology