Synthetic RNA Controllers for Programming Mammalian Cell Fate and Function

Abstract

The original objectives within Task 1 fell under several categories, including to: (i) extend the multi-input and multi-output control capabilities of RNA devices, (ii) develop multi-functional device platforms that support complex regulatory strategies, and (iii) develop an RNA device platform that controls posttranslational events. During the course of the DARPA contract we met the described goals of the first two objectives; however, the third objective, to develop an RNA device platform that controls posttranslational events, was not pursued after the first year of the agreement. This decision was based on progress made on this objective and the priorities of the program.

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Document Details

Document Type
Technical Report
Publication Date
Nov 04, 2015
Accession Number
ADA625712

Entities

People

  • Christina D. Smolke

Organizations

  • Stanford University

Tags

Communities of Interest

  • Autonomy
  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Agreements
  • Cell Physiological Processes
  • Cells
  • Computer Programming
  • Contracts
  • Control Systems
  • Data Analysis
  • Demographic Cohorts
  • Detectors
  • Engineering
  • Eukaryotes
  • Gene Expression
  • Information Processing
  • Molecules
  • Platforms
  • Proteins
  • Small Molecules

Readers

  • Adaptive Control and Estimation with Uncertainty in Dynamic Systems.
  • Government Contracting/Procurement.
  • Systems Analysis and Design