A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury

Abstract

A small, lightweight microdevice has been developed for activity-dependent stimulation (ADS) and successfully tested for functionality in both anesthetized and ambulatory rats. Further, in semi-chronic experiments in rats with TBI using this microsystem, an unprecedented, potent effect of ADS on motor performance has been demonstrated, as compared to control rats (injured but no microdevice) and open-loop stimulation (OLS) rats. Specifically, open-loop stimulation does result in some recovery after injury, but ADS is significantly more efficacious, resulting in recovery to normal ranges of performance within 2 weeks after injury. In the final stage of this funding period, we will prepare to extend these findings to non-human primates as we finalize a) the optimal parameters for the primate TBI model and b) the design and construction of the primate microdevice.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2014
Accession Number
ADA625874

Entities

People

  • Randolph J Nudo

Organizations

  • University of Kansas Medical Center

Tags

DTIC Thesaurus Topics

  • Brain
  • Brain Injuries
  • Cerebral Cortex
  • Closed Loop Systems
  • Cognitive Impairment
  • Composite Materials
  • Computer Programming
  • Computers
  • Department Of Defense
  • Diseases And Disorders
  • Electrical Engineering
  • Firing Rate
  • Frequency
  • Neuroplasticity
  • Neurosciences
  • Skull
  • Statistical Analysis

Fields of Study

  • Biology

Readers

  • Neuroscience
  • Software Engineering
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.