Wound Status Early Outcome Sensor and 3D Construct Development

Abstract

Early identification of the specific proteins, which indicate delayed healing are critical to long-term success of the patient and the development of new treatments. It is the objective of this research to correlate changes in the proteome of wounds with clinical outcome and develop technology to sense these changes. A technique to classify a sampling timepoint based on a sliding 3 timepoint scale was developed. Proteomic analysis of the wound fluid utilized antibody dependent and independent techniques. The quantitative microarray demonstrated significantly different levels of S100A8 and TGFBR3 between healing and worsening wounds. The utilization of SRM-MS for wound fluid analysis is a significant development in the path to wound outcome diagnosis. Ultimately this work may allow the development of personalized wound care based on the proteomic characteristics of the wound.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2015
Accession Number
ADA625888

Entities

People

  • Laura E. Edsberg

Organizations

  • Daemen University

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Biomedical And Dental Materials
  • Blood Coagulation Factors
  • Carrier Proteins
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Lymphocytes
  • Peptide Growth Factors
  • Peptides
  • Polymer Chemistry
  • Polymeric Films
  • Proteins
  • Proteomics

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Technology Areas

  • Biotechnology