Intravesical NGF Antisense Therapy Using Lipid Nanoparticle for Interstitial Cystitis

Abstract

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating disorder characterized by persistent pelvic pain associated with bladder symptoms including urinary frequency and urgency. Previous studies have indicated that overexpression of nerve growth factor (NGF) is a important factor in the symptom development of IC/BPS. This project evaluates the feasibility of an anti-NGF bladder drug delivery system as a potential investigational drug product. The project aims include exploration, manufacture, characterization, and nonclinical animal testing of a liposome NGF-antisense formulation targeting IC/BPS. During the project period investigators conducted nonclinical experiments and analyzed results from an animal efficacy experiment conducted during the previous period. The project is ongoing.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
ADA625990

Entities

People

  • David Chancellor
  • Michael B Chancellor
  • Michele Gruber
  • Naoki Yoshimura

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Cells
  • Chemistry
  • Data Storage Systems
  • Health Services
  • Lymphocytes
  • Pain
  • Peripheral Nervous System
  • Pharmacies
  • Proteins
  • Urinary Tract

Fields of Study

  • Medicine

Readers

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Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech