Meningococcal Polysaccharide Vaccine Failure in a Patient with C7 Deficiency and a Decreased Anticapsular Antibody Response

Abstract

This is a case report of a military service member who received the meningococcal vaccine but died of the disease 15 months later. He had terminal complement component deficiency (TCCD), and his anti-capsular antibody levels were inadequate. This case highlights the fact that some individuals with TCCD have an impaired or short-lived response to vaccination with meningococcal capsular polysaccharide, and it underscores the appropriateness of an initial two-dose series.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2012
Accession Number
ADA625995

Entities

People

  • Michael P. Broderick
  • Paul B. Keiser

Organizations

  • Naval Health Research Center

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Blood
  • Carbohydrates
  • Cell Count
  • Deficiencies
  • Diseases And Disorders
  • Gram-Negative Bacterial Infections
  • Health
  • Health Services
  • Immunoglobulins
  • Immunoproteins
  • Infection
  • Meningitis
  • Polysaccharides
  • Terminals
  • Vaccination
  • Vaccines

Fields of Study

  • Medicine

Readers

  • Housing Policy Studies in Military Families with Privatization and Telomerase Allowance Units, Multi-Family Housing, and Telomere Lengths.
  • Immunology

Technology Areas

  • Biotechnology