Low Ultraviolet B and Increased Risk of Brain Cancer: An Ecological Study of 175 Countries

Abstract

The purpose of this study was to determine whether an inverse association exists between latitude, solar ultraviolet B (UVB) irradiance, modeled 25-hydroxyvitamin D [25(OH)D] levels, and incidence rates of cancer of the brain. Incidence rates of brain cancer were higher at higher latitudes (R2 for males = 0.45, p<0.0001: females R2 = 0.35, p <0.0001). After adjustment for potential confounders, UVB irradiance (p<0.0001) and modeled serum 25 (OH)D were inversely associated with incidence rates. Countries with low solar UVB irradiance and estimated mean serum 25(OH)D levels generally had higher age-standardized incidence rates of brain cancer. Since this was an ecological study, further research would be worthwhile of the association of prediagnostic serum 25(OH)D with incidence rate in studies of cohorts of individuals.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2009
Accession Number
ADA626001

Entities

People

  • Cedric F. Garland
  • Edward Doerr Gorham
  • Frank C. Garland
  • Sharif B. Mohr
  • William B. Grant

Organizations

  • Naval Health Research Center

Tags

DTIC Thesaurus Topics

  • Agriculture
  • Bladder Cancer
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Epithelial Cells
  • Health
  • Health Care
  • Health Services
  • Intercellular Junctions
  • Ionizing Radiation
  • Neoplasms
  • Nervous System
  • Neuroglia
  • United Nations
  • United States
  • Vitamin D

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