Collaborative Core Research Program for Chemical-Biological Warfare Defense
Abstract
Classical chemical nerve agents (CNAs) and numerous emerging chemical threats (ECTs) collectively referred to as chemical warfare agents (CWAs) share acetylcholinesterase (AChE) inactivation as a common target for their respective modes of action. To date, there is no known countermeasure with therapeutic efficacy for rescuing enzyme activity against a broad-spectrum of CWAs. Therefore, the major thrust of the work being performed by the Biological Modeling Group (BMG) at AFRL and its collaborators at the University of Cincinnati's Metabolic Diseases Institute (UC-MDI) and the Battelle Memorial Institute's Biomedical Research Center (BBRC) is focused on developing novel, broad spectrum countermeasures involving small molecule allosteric modulators for AChE activity. The research team hypothesizes that by utilizing allosteric modulation of the enzyme activity, treatment before or shortly after CWA exposure would protect the enzyme from inhibition.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 04, 2015
- Accession Number
- ADA626004
Entities
People
- Amy B. Ghering
- Andrea Hoffmann
- Christopher D. Ruark
- Elaine A. Merrill
- Jeffery M. Gearhart
- Lee D. Poeppelman
- Meghan K. Makley
- Richard R Chapleau
- Tammie R. Covington
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine