St. John's Wort for Major Depressive Disorder: A Systematic Review

Abstract

This systematic review synthesized evidence of St. John s wort (SJW) for the treatment of major depressive disorder (MDD) (PROSPERO record CRD42015016406). In November 2014, we searched nine electronic databases, as well as bibliographies of existing systematic reviews, to identify randomized controlled trials (RCTs) testing the efficacy and safety of SJW to treat adults with MDD. Two independent reviewers screened publications using predetermined eligibility criteria, abstracted study-level information, and assessed the quality of included studies. Outcomes of interest included changes in depressive symptomatology, quality of life, and adverse effects. Efficacy meta-analyses used the Hartung- Knapp-Sidik-Jonkman method for random-effects models. Quality of evidence was assessed using the GRADE approach.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2015
Accession Number
ADA626192

Entities

People

  • Alicia R. Maher
  • Eric Apaydin
  • Jeremy N. Miles
  • Marika Booth
  • Melony E. Sorbero
  • Roberta M. Shanman
  • Susanne Hempel

Organizations

  • RAND Corporation

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antidepressants
  • Anxiety Disorders
  • Chemical Synthesis
  • Depression
  • Drug Abuse
  • Health Services
  • Medical Personnel
  • Pharmacies
  • Psychiatry
  • Tranquilizing Agents

Fields of Study

  • Medicine

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