Targeting Alpha5 Beta1 Integrin to Prevent Metastatic Breast Cancer Cell Invasion: PhScN Target Site Definition and Plasma Stability
Abstract
We proposed to test PHSCN and PhScN derivatives with modifications of the N-- or C--termini, and/or cysteine side chain to determine the initial spatial constraints of the binding pocket of the ligand to its target site. This will aid in the selection of crosslinking agents, modifications, tag additions and strategies for determination of the target site(s) to be performed in Aim 2, and will lay the foundation for determining the structure-activity relationships (SARS) of these inhibitors with the target.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2014
- Accession Number
- ADA626549
Entities
People
- Donna L. Livant
Organizations
- University of Michigan