Modulating Hippocampal Plasticity with In Vivo Brain Stimulation
Abstract
Researchers have used brain stimulation such as transcranial direct current stimulation on human subjects to alleviate symptoms of neurological disorders and enhance their performance. Here, using rats, we have investigated the potential mechanisms of how in vivo brain stimulation can produce such effect. We recorded directly on viable brain slices from rats after brain stimulation to detect lasting changes in pattern of neuronal activity. Our results showed that 30 min of brain stimulation in rats induced a robust enhancement in synaptic plasticity, a neuronal process critical for learning and memory. Understanding such molecular effects will lead to a better understanding of the mechanisms by which brain stimulation produces its effects on cognition and performance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 16, 2015
- Accession Number
- ADA627269
Entities
People
- Joyce G. Rohan
- Kim A. Carhuatanta
- Molly K. Miklasevich
- Ryan Jankord
- Shawn M. Mcinturf
Organizations
- Air Force Research Laboratory