A Treatment Worth Its Salt?
Abstract
A new era in the treatment of shock began with the 1980 report that hypertonic (7.5%) saline (HS) could resuscitate dogs in hemorrhagic shock (1). This study sparked numerous investigations into the benefits of HS either alone or with dextran or hetastarch to resuscitate experimental animals from hemorrhagic hypotension (cited in Ref. 2) and led to several clinical trials in patients with traumatic hypotension (3 5). Other studies investigated the efficacy of these fluids in traumatic brain injury or intracranial hemorrhage (5, 6). These studies provided solid evidence for the physiologic effects of hypertonic fluids on expanding plasma volume and improving cardiac output, regional blood flows, and the microcirculation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2008
- Accession Number
- ADA627753
Entities
People
- Michael A. Dubick
Organizations
- United States Army Institute of Surgical Research