Cytoprotective Effect of Caffeic Acid Phenethyl Ester (CAPE) and Catechol Ring-Fluorinated CAPE Derivatives Against Menadione-Induced Oxidative Stress in Human Endothelial Cells

Abstract

Caffeic acid phenethyl ester (CAPE), a natural polyphenolic compound with many biological activities, has been shown to be protective against ischemia reperfusion injury. We have synthesized six new catechol ring-fluorinated CAPE derivatives and evaluated their cytotoxic and cytoprotective effects against menadione-induced cytotoxicity in human umbilical vein endothelial cells. These results provide some insights into the structural basis of CAPE cytoprotection in this assay, which does not appear to be based solely on direct antioxidant properties.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Mar 31, 2006
Accession Number
ADA628024

Entities

People

  • Phillip D. Bowman
  • Salomon Stavchansky
  • Sean M. Kerwin
  • Xinyu Wang

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Acrylic Acid
  • Analogs
  • Apoptosis
  • Benzaldehydes
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chromatography
  • Column Chromatography
  • Endothelial Cells
  • Free Radicals
  • Oxidative Stress
  • Standards
  • Statistical Analysis
  • Three Dimensional
  • Vascular Diseases

Fields of Study

  • Chemistry

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular and Cellular Biochemistry